Primary biliary cholangitis in a young male with isolated jaundice: a case report
DOI:
https://doi.org/10.55204/trc.v6i2.e501Keywords:
colangitis biliar primaria, ictericia colestásica, hombre joven, enfermedad hepatica autoinmuneAbstract
Its initial clinical presentation is usually insidious, with manifestations such as fatigue and pruritus in a significant percentage of cases, while overt jaundice is usually indicative of advanced disease. Diagnosis is based on a cholestatic pattern in liver function tests, the detection of specific autoantibodies—mainly antimitochondrial antibodies (AMA), present in 90–95% of cases—and the exclusion of other causes of cholestatic liver disease. First-line treatment is ursodeoxycholic acid, which improves transplant-free survival and slows disease progression. We present the case of a young male patient with isolated jaundice and weight loss, in whom the diagnosis of PBC was confirmed by positive AMA and liver biopsy. This case highlights the importance of recognizing this entity in atypical populations by age and sex, in order to initiate timely treatment and improve prognosis
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1. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017;67(1):145–172. DOI: 10.1016/j.jhep.2017.03.022.
2. Lleo A, Jepsen P, Morenghi E, et al. Evolving trends in female to male incidence and male mortality of primary biliary cholangitis. Sci Rep. 2016;6:25906. DOI: 10.1038/srep25906.
3. Carbone M, Boonstra K, Heathcote EJ, et al. Gender and age distribution in primary biliary cirrhosis: a multi-center international study. Hepatology. 2013;58(1):204–216. DOI: 10.1002/hep.26148.
4. Lindor KD, Bowlus CL, Boyer J, et al. Primary Biliary Cholangitis: 2018 Practice Guidance from the AASLD. Hepatology. 2019;69(1):394–419. DOI: 10.1002/hep.30145.
5. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med. 2005;353(12):1261–1273. DOI:10.1056/NEJMra043898.
6. Gungabissoon U, Smith HT, von Maltzahn R, Logie J, Fairburn-Beech J, Ma L, et al. Pruritus in primary biliary cholangitis is under-recorded in patient medical records. BMJ Open Gastroenterol [Internet]. 2024;11(1):e001287. Disponible en: http://dx.doi.org/10.1136/bmjgast-2023-001287
7. Trivella J, John BV, Levy C. Primary biliary cholangitis: Epidemiology, prognosis, and treatment. Hepatol Commun [Internet]. 2023;7(6). Disponible en: http://dx.doi.org/10.1097/HC9.0000000000000179
8. Sarcognato S, Sacchi D, Grillo F, Cazzagon N, Fabris L, Cadamuro M, et al. Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis. Pathologica [Internet]. 2021;113(3):170–84. Disponible en: http://dx.doi.org/10.32074/1591-951X-245
9. Shah SK, Bowlus CL. Autoimmune markers in primary biliary cholangitis. Clin Liver Dis [Internet]. 2024;28(1):93–101. Disponible en: http://dx.doi.org/10.1016/j.cld.2023.07.002
10. Leung KK, Hirschfield GM. Autoantibodies in primary biliary cholangitis. Clin Liver Dis [Internet]. 2022;26(4):613–27. Disponible en: http://dx.doi.org/10.1016/j.cld.2022.06.004
11. Nevens F, Andreone P, Mazzella G, et al. A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. N Engl J Med. 2016;375(7):631–643. doi:10.1056/NEJMoa1509840.
12. Corpechot C, Chazouillères O, Rousseau A, et al. A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis. N Engl J Med. 2018;378(23):2171–2181. doi:10.1056/NEJMoa1714519.
13. Scheuer P. Primary biliary cirrhosis. Proc R Soc Med. 1967;60(12):1257–1260. doi:10.1177/003591576706001205.
14. Ludwig J, Dickson ER, McDonald GS. Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Anat Histol. 1978;379(2):103–112. doi:10.1007/BF00432479.
15. Natarajan Y, Tansel A, Patel P, et al. Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis. Dig Dis Sci. 2021;66(7):2439–2451. doi:10.1007/s10620-020-06498-7.
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