Postoperative evolution of intestinal atresias and stenosis at the Regional Center for Neonatal Surgery

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DOI:

https://doi.org/10.55204/trc.v3i2.e236

Keywords:

intestinal atresias and stenosis, potsoperative evolution, surgical treatment, short bowel syndrome

Abstract

Introduction: Intestinal atresias and stenosis constitute the main etiology of organic digestive obstruction in the newborn stage. In recent years, the lethality of these conditions has decreased significantly, from 36.5 % in 1969 to 10 % in the most current reviews.

Objective: To identify the prognostic surgical factors in patients diagnosed at the Regional Center for Neonatal Surgery in Holguin, Cuba, during the period from January 2010 to December 2022.

Methods: A descriptive, retrospective study of 54 patients diagnosed with for these affections, which were related to general, epidemiological, and clinical variables.

Results: Mortality in the series was 11.1 %. The duodenal anatomical site was predominant (62.9 %) and primary anastomosis was the initial surgical technique (77.7 %). Unfavorable evolution was observed in 29.7 % and comorbidity was in the neonatal period (64.8 %) and in the first year of life (54.9 %).

Conclusions: The most significant prognostic factors were the association with complex congenital malformations and low birth weight. The inadequate evolution was favored by the presence of unfavorable anatomical conditions, the development of postoperative enteropathy, as well as prolonged fasting times, parenteral nutrition and, therefore, hospitalization. Follow-up should be directed at growth and development disorders, as well as malabsorption associated with short bowel syndrome. The proper functioning of the current protocols in use will improve the quality of life of these patients.

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References

Bales C, Liacouras CA. Philadelphia: Elsevier Inc.; 2016. Intestinal atresia, stenosis and malrotation. 20th ed. Kliegman RM, Stanton BF, St Geme JW, Schor NF, editor. Nelson Textbook of pediatrics; pp. 1800–1804.

Pijpers AGH, Eeftinck Schattenkerk LD, de Vries R, Broers CJM, Straver B, van Heurn ELW, Musters GD, Gorter RR, Derikx JPM. Cardiac anomalies in children with congenital duodenal obstruction: a systematic review with meta-analysis. Pediatr Surg Int. 2023 Mar 26;39(1):160. https://pubmed.ncbi.nlm.nih.gov/36967411

Mustafawi AR, Hassan ME. Congenital duodenal obstruction in children: a decade's experience. Eur J Pediatr Surg. 2008 Apr; 18(2): 93-7. https://pubmed.ncbi.nlm.nih.gov/18437652

Arena F, Impellizzeri P, Scalfari G, Antonuccio P, Montalto AS, Racchiusa S, Romeo C. An uncommon case of associate intrinsic and extrinsic stenosis of the duodenum in newborn. Pediatr Med Chir. 2008 Jul-Aug;30(4):212-4. https://pubmed.ncbi.nlm.nih.gov/19216206

Kostouros A, Koliarakis I, Natsis K, Spandidos DA, Tsatsakis A, Tsiaoussis J. Large intestine embryogenesis: Molecular pathways and related disorders (Review). Int J Mol Med. 2020 Jul;46(1):27-57. https://pubmed.ncbi.nlm.nih.gov/32319546

Morris G, Kennedy A Jr. Small Bowel Congenital Anomalies: A Review and Update. Surg Clin North Am. 2022 Oct; 102(5): 821-835. https://pubmed.ncbi.nlm.nih.gov/36209748

Merritt RJ, Cohran V, Raphael BP, Sentongo T, Volpert D, Warner BW, et al. Nutrition Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Intestinal Rehabilitation Programs in the Management of Pediatric Intestinal Failure and Short Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2017 Nov; 65(5): 588-596. https://pubmed.ncbi.nlm.nih.gov/28837507

Zhu H, Gao R, Alganabi M, Dong K, Ganji N, Xiao X, et al. Long-term surgical outcomes of apple-peel atresia. J Pediatr Surg 2019; 54: 2503-2508 https://doi.org/10.1016/j.jpedsurg.2019.08.045

Morris JK, Springett AL, Greenlees R, Loane M, Addor MC, Arriola L, et al. Trends in congenital anomalies in Europe from 1980 to 2012. PLoS One. 2018 Apr 5;13(4):e0194986. https://pubmed.ncbi.nlm.nih.gov/29621304

Wales PW, De Silva N, Kim J, Lecce L, To T, Moore,A. Neonatal Short Bowel Syndrome: Population-Based Estimates of Incidence and Mortality Rates. J. Pediatr. Surg. 2004, 39, 690–695. https://doi.org/10.1016/j.jpedsurg.2004.01.036

Quintero Nicó W, Trinchet Soler R. Morbilidad y mortalidad de la Cirugía Neonatal en Holguín 1990-2006. Madrid: Editorial Académica española; 2011. https://www.centrallibrera.com/libro/morbilidad-y-mortalidad-de-la-cirugia-neonatal-en-holguin_89884

Piper HG, Alesbury J, Waterford SD, Zurakowski D, Jaksic T. Intestinal atresias: factors affecting clinical outcomes. J Pediatr Surg. 2008 Jul;43(7):1244-8. https://pubmed.ncbi.nlm.nih.gov/18639676

Deguchi K, Tazuke Y, Matsuura R, Nomura M, Yamanaka H, Soh H, Yoneda A. Factors Associated With Adverse Outcomes Following Duodenal Atresia Surgery in Neonates: A Retrospective Study. Cureus. 2022 Feb 17; 14(2): e22349. https://pubmed.ncbi.nlm.nih.gov/35371797

Mangray, H., Ghimenton, F. & Aldous, C. Jejuno-ileal atresia: its characteristics and peculiarities concerning apple peel atresia, focused on its treatment and outcomes as experienced in one of the leading South African academic centres. Pediatr Surg Int 36, 201–207 (2020). https://doi.org/10.1007/s00383-019-04594-y

Burjonrappa S, Crete E, Bouchard S. Comparative outcomes in intestinal atresia: a clinical outcome and pathophysiology analysis. Pediatr Surg Int. 2011 Apr; 27(4): 437-42. https://pubmed.ncbi.nlm.nih.gov/20820789

Aboalazayem A, Ragab M, Magdy A, Bahaaeldin K, Shalaby A. Outcome of Tapering Enteroplasty in Managing Jejunoileal Atresia. J Indian Assoc Pediatr Surg. 2022 Nov-Dec;27(6):666-669. https://pubmed.ncbi.nlm.nih.gov/36714492

Rodriguez Mejia, Evaldo Jesus. "Co-morbilidad y letalidad en el primer año de vida en niños con atresia yeyunoileal". (Trabajo de grado de especialización). Universidad Nacional Autónoma de México, México. 2005 https://repositorio.unam.mx/contenidos/464863

Bracho-Blanchet E, González-Chávez A, Dávila-Pérez R, Zalies C. Factores pronósticos para la mortalidad en atresia intestinal. Cir Cir 2012; 80: 345-351. www.researchgate.net/publication/235394665

Chandra R, Kesavan A. Current treatment paradigms in pediatric short bowel syndrome. Clin J Gastroenterol. 2018 Apr; 11(2): 103-112. https://pubmed.ncbi.nlm.nih.gov/29280097

IJsselstijn H, Gischler SJ, Wijnen RMH, Tibboel D. Assessment and significance of long-term outcomes in pediatric surgery. Semin Pediatr Surg. 2017; 26(5): 281-285. https://pubmed.ncbi.nlm.nih.gov/29110823

Joda AE, Abdullah AF. Outcomes of end-to-side oblique anastomosis as a surgical technique for jejuno-ileal atresia. Updates Surg. 2019 Sep;71(3):587-593. https://pubmed.ncbi.nlm.nih.gov/31243726

Singh V, Pathak M. Congenital Neonatal Intestinal Obstruction: Retrospective Analysis at Tertiary Care Hospital. J Neonatal Surg. 2016 Oct 10; 5(4): 49. https://pubmed.ncbi.nlm.nih.gov/27896157

Zeng FTA, Mbaye PA, Gueye D, Seck NF, Wellé IB, Niang R, et al. Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal. World J Pediatr Surg. 2023 Jan 19; 6(1): e000463. https://pubmed.ncbi.nlm.nih.gov/36733454

Jana, A., Saha, U.R., Reshmi, R.S. et al. Relationship between low birth weight and infant mortality: evidence from National Family Health Survey 2019-21, India. Arch Public Health 81, 28 (2023). https://doi.org/10.1186/s13690-023-01037-y

Best KE, Tennant PW, Addor MC, Bianchi F, Boyd P, Calzolari E, Dias CM, et al. J. Epidemiology of small intestinal atresia in Europe: a register-based study. Arch Dis Child Fetal Neonatal Ed. 2012 Sep; 97(5): F353-8. https://pubmed.ncbi.nlm.nih.gov/22933095

Kim JY, You JY, Chang KH, Choi SJ, Oh SY, Seo JM, et al. Association Between Prenatal Sonographic Findings of Duodenal Obstruction and Adverse Outcomes. J Ultrasound Med. 2016 Sep;35(9):1931-8. https://pubmed.ncbi.nlm.nih.gov/27466262

Demirci O, Eriç Özdemir M, Kumru P, Celayir A. Clinical significance of prenatal double bubble sign on perinatal outcome and literature review. J Matern Fetal Neonatal Med. 2022 May;35(10):1841-1847. https://pubmed.ncbi.nlm.nih.gov/33455511

Saalabian K, Friedmacher F, Theilen TM, Keese D, Rolle U, Gfroerer S. Prenatal Detection of Congenital Duodenal Obstruction-Impact on Postnatal Care. Children (Basel). 2022 Jan 26;9(2):160. https://pubmed.ncbi.nlm.nih.gov/35204881

Yin C, Tong L, Ma M, Tan X, Luo G, Fei Z, Nie D. The application of prenatal ultrasound in the diagnosis of congenital duodenal obstruction. BMC Pregnancy Childbirth. 2020 Jul 3;20(1):387. https://pubmed.ncbi.nlm.nih.gov/32620086

Bishop JC, McCormick B, Johnson CT, Miller J, Jelin E, Blakemore K, Jelin AC. The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies. Fetal Diagn Ther. 2020;47(2):98-103. https://pubmed.ncbi.nlm.nih.gov/31167209

Rubio EI, Blask AR, Badillo AT, Bulas DI. Prenatal magnetic resonance and ultrasonographic findings in small-bowel obstruction: imaging clues and postnatal outcomes. Pediatr Radiol. 2017 Apr;47(4):411-421. https://pubmed.ncbi.nlm.nih.gov/28116474

Carroll AG, Kavanagh RG, Ni Leidhin C, Cullinan NM, Lavelle LP, Malone DE. Comparative Effectiveness of Imaging Modalities for the Diagnosis of Intestinal Obstruction in Neonates and Infants: A Critically Appraised Topic. Acad Radiol. 2016 May;23(5):559-68. https://pubmed.ncbi.nlm.nih.gov/26857524

Yang Y, He P, Li DZ. Clinical outcome of pregnancies with the prenatal double bubble sign - a five-year experience from one single centre in mainland China. J Obstet Gynaecol. 2018 Feb;38(2):206-209. https://pubmed.ncbi.nlm.nih.gov/28880692

Jerry AL, Amboiram P, Balakrishnan U, Chandrasekaran A, Agarwal P, Devi U. Clinical Profile, Outcomes and Predictors of Mortality in Neonates Operated for Gastrointestinal Anomalies in a Tertiary Neonatal Care Unit- An Observational Study. J Indian Assoc Pediatr Surg. 2022 May-Jun; 27(3): 287-292. https://pubmed.ncbi.nlm.nih.gov/35733590

Osuchukwu OO, Rentea RM. Ileal Atresia. 2023 Apr 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. https://pubmed.ncbi.nlm.nih.gov/32491332

Chen QJ, Gao ZG, Tou JF, Qian YZ, Li MJ, Xiong QX, Shu Q. Congenital duodenal obstruction in neonates: a decade's experience from one center. World J Pediatr. 2014 Aug;10(3):238-44. https://pubmed.ncbi.nlm.nih.gov/25124975

Gfroerer S, Theilen TM, Fiegel HC, Esmaeili A, Rolle U. Comparison of outcomes between complete and incomplete congenital duodenal obstruction. World J Gastroenterol. 2019 Jul 28; 25(28): 3787-3797. https://pubmed.ncbi.nlm.nih.gov/31391773

López-Díaz NG, Oliver-García EF, Núñez-Enríquez JC. Manejo quirúrgico de atresia duodenal por páncreas anular y atresia intestinal IIIb [Surgical management of duodenal atresia due to annular pancreas and intestinal atresia IIIb]. Rev Med Inst Mex Seguro Soc. 2023 Jan 2;61(1):123-129. https://pubmed.ncbi.nlm.nih.gov/36542807

Chen LY, Cabrera-Bou VF, Casas-Melley AT. Dual duodenojejunostomies in the repair of megaduodenum, duodenal stenosis and prior missed diagnosis of annular pancreas. BMJ Case Rep. 2022 Feb 28;15(2):e248219. https://pubmed.ncbi.nlm.nih.gov/35228246

Zuccarello B, Spada A, Centorrino A, Turiaco N, Chirico MR, Parisi S. The Modified Kimura's Technique for the Treatment of Duodenal Atresia. Int J Pediatr. 2009;2009:175963. https://pubmed.ncbi.nlm.nih.gov/19946416

Schmedding A, Hutter M, Gfroerer S, Rolle U. Jejunoileal Atresia: A National Cohort Study. Front Pediatr. 2021 May 31; 9: 665022. https://pubmed.ncbi.nlm.nih.gov/34136442

Sehgal S, Sandler AD, Alfred Chahine A, Mohan P, Torres C. Ostomy in continuity: A novel approach for the management of children with complex short bowel syndrome. J Pediatr Surg. 2018 Oct;53(10):1989-1995. doi: 10.1016/j.jpedsurg.2018.02.059. Epub 2018 Mar 4. https://pubmed.ncbi.nlm.nih.gov/29602547

Rashwan H, Kotb M. T-tube enterostomy in the management of apple-peel atresia: A case series from a single center. Front Pediatr. 2022 Nov 9; 10: 1003508. https://pubmed.ncbi.nlm.nih.gov/36440335

Aroonsaeng D, Losty PD, Thanachatchairattana P. Postoperative feeding in neonatal duodenal obstruction. BMC Pediatr. 2022 Aug 3; 22(1): 467. https://pubmed.ncbi.nlm.nih.gov/35922792

Bairdain S, Yu DC, Lien C, Khan FA, Pathak B, Grabowski MJ, et al. A modern cohort of duodenal obstruction patients: predictors of delayed transition to full enteral nutrition. J Nutr Metab. 2014; 2014: 850820. https://pubmed.ncbi.nlm.nih.gov/25210625

Eeftinck Schattenkerk LD, Musters GD, Nijssen DJ, de Jonge WJ, de Vries R, van Heurn LWE, et al. The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method. Innov Surg Sci. 2021 Aug 17;6(4):127-150. https://pubmed.ncbi.nlm.nih.gov/35937853

Kotelnikova LP, Repin MV, Shatrova NA. Pozdnee oslozhnenie khirurgicheskogo lecheniya atrezii dvenadtsatiperstnoi kishki v neonatal'nom periode [Delayed complication of surgical treatment of duodenal atresia in neonatal period]. Khirurgiia (Mosk). 2023;(5):111-116. https://pubmed.ncbi.nlm.nih.gov/37186659

Wang X, Lin K, Liu H, Hu Z, Ye G, Sheng Q, et al. Endoscopic Balloon Dilatation-Based Membrane Resection for Membranous Duodenal Stenosis: A Feasibility and Safety Study (With Video). J Pediatr Gastroenterol Nutr. 2023 Aug 1; 77(2): e36-e41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348657

Treider M, Engebretsen AH, Skari H, Bjørnland K. Is postoperative transanastomotic feeding beneficial in neonates with congenital duodenal obstruction? Pediatr Surg Int. 2022 Mar;38(3):479-484. https://pubmed.ncbi.nlm.nih.gov/34910223

Biradar N, Gera P, Rao S. Trans-anastomotic tube feeding in the management of congenital duodenal obstruction: a systematic review and meta-analysis. Pediatr Surg Int. 2021 Nov;37(11):1489-1498. https://pubmed.ncbi.nlm.nih.gov/34212223

Bethell GS, Long AM, Knight M, Hall NJ; BAPS-CASS. Congenital duodenal obstruction in the UK: a population-based study. Arch Dis Child Fetal Neonatal Ed. 2020 Mar;105(2):178-183. https://pubmed.ncbi.nlm.nih.gov/31229958

Lum Min SA, Imam M, Zrinyi A, Shawyer AC, Keijzer R. Post-discharge follow-up of congenital duodenal obstruction patients: a systematic review. Pediatr Surg Int. 2023 Jul 25;39(1):239. https://pubmed.ncbi.nlm.nih.gov/37490166

Stanescu AL, Liszewski MC, Lee EY, Phillips GS. Neonatal Gastrointestinal Emergencies: Step-by-Step Approach. Radiol Clin North Am. 2017 Jul;55(4):717-739. https://pubmed.ncbi.nlm.nih.gov/28601177

Muff JL, Sokolovski F, Walsh-Korb Z, Choudhury RA, Dunn JCY, Holland-Cunz SG, et al. SurgicalTreatment of Short Bowel Syndrome—The Past, the Present and the Future, a Descriptive Review of the Literature. Children 2022, 9, 1024. https://doi.org/10.3390/children9071024

Mayer O, Kerner JA. Management of short bowel syndrome in postoperative very low birth weight infants. Semin Fetal Neonatal Med. 2017 Feb;22(1):49-56. https://pubmed.ncbi.nlm.nih.gov/27576105

Premkumar MH, Soraisham A, Bagga N, Massieu LA, Maheshwari A. Nutritional Management of Short Bowel Syndrome. Clin Perinatol. 2022 Jun;49(2):557-572. https://pubmed.ncbi.nlm.nih.gov/35659103

Quigley EMM, Murray JA, Pimentel M. AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review. Gastroenterology. 2020 Oct;159(4):1526-1532. https://pubmed.ncbi.nlm.nih.gov/32679220

Chen Y, Zhu LD, Zhou L, Guan AH, Wang ZY, Xiao D, Ma XP, Ren F. The multivariate cox regression model for complete enteral nutrition after primary anastomosis in neonates with intestinal atresia. Front Pediatr. 2022 Dec 12; 10: 1071056. https://pubmed.ncbi.nlm.nih.gov/36578664

Mihatsch WA, Braegger C, Bronsky J, Cai W, Campoy C, Carnielli V, et al. ESPGHAN/ESPEN/ESPR/CSPEN Guidelines on Pediatric Parenteral Nutrition. Clin. Nutr. 2018, 37, 2303–2305. https://www.clinicalnutritionjournal.com/article/S0261-5614(18)30215-2/fulltext

Hernandez, Francisco; Andres, Ane M.; Lopez-Santamaria, Manuel. Long-term results of surgery for bowel lengthening: how many transplants are avoided, for which patients?. Current Opinion in Organ Transplantation 23(2):p 207-211, April 2018. https://doi.org/10.1097/MOT.0000000000000508

Ludwig K, De Bartolo D, Salerno A, Ingravallo G, Cazzato G, Giacometti C, Dall'Igna P. Congenital anomalies of the tubular gastrointestinal tract. Pathologica. 2022 Feb; 114(1): 40-54. https://pubmed.ncbi.nlm.nih.gov/35212315

Choi G, Je BK, Kim YJ. Gastrointestinal Emergency in Neonates and Infants: A Pictorial Essay. Korean J Radiol. 2022 Jan; 23(1): 124-138. https://pubmed.ncbi.nlm.nih.gov/34983099

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2023-08-29

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Health Sciences

How to Cite

Quintero Nicó, W., Álvarez Cruz, E. Y., Velecela Ardila, E. A., Allieri Fernández, J. G., Campbell Burgos, N. W., & Rojas Yela, E. R. (2023). Postoperative evolution of intestinal atresias and stenosis at the Regional Center for Neonatal Surgery. Tesla Revista Científica, 3(2), e236. https://doi.org/10.55204/trc.v3i2.e236

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